Which virus is associated with skin and mucous membrane infections?

The herpes simplex virus is primarily associated with infections of the skin and mucous membranes. This virus can manifest in several forms, the most common being oral herpes, which leads to cold sores or fever blisters around the mouth, and genital herpes, which causes sores in the genital area. Herpes simplex is known for its ability to reside in the body in a dormant state after the initial infection, leading to periodic outbreaks that affect the skin and mucous tissues.

Other viruses listed, while significant in their own right, are associated with different types of infections. Hepatitis B primarily affects the liver, influenza targets the respiratory system, and HIV principally affects the immune system. Therefore, herpes simplex is specifically recognized for its impact on skin and mucous membranes, making it the correct choice in this context.